In this paper, the Regional building process of economic and political dimensions of Central Asia in light of various factors checked, some of the factors include: Mutual cooperation, Border disputes, Geographic, Hydro politics, Disputes relating to energy and the difference between the heads of states and non-identical influence each of them in a single region. In the economic sector article, on bilateral relations Including Cross-border trade and non-systematic subdivision of the property, is mentioned. Also in Content analysis of external actors pictures and Europe Union programs, America, Turkey, China and Russia have been analyzed and Concluded, Although  Regional building in Central Asia Provide adequate facilities for developing countries, But it seems that this process is not available in a short time.
            The Hypothesis is That Why has so far not been successful regional Building in Central Asia? In response to the question paper, it is hypothesized that it seams inter-regional political, security, economic and cultural Factors and barriers ant also Trans-regional actors Interference, led to the failure of regionalism in Central Asian. Article descriptive - analytic method was carried out.