Expansion of NATO and the EU to the East created an atmosphere of strategic uncertainty in Western government relations with Russia, at the cost of intensification of security issue all over Central Eurasia and prompted Moscow into taking tough, and in some cases inconsistent with regional peace and stability, decisions. In these conditions, the convergence of the governments desiring change of global governance can alleviate the aggressive behavior towards the arrogance system and pursue the concept of change in the status quo in a more peaceful manner. The present paper explains this approach based on the impact of “Iran’s Special Ties with Russia in Strategic Spheres” on “Predictability of Moscow Behaviors and Alleviation of Security Challenge in Central Eurasia due to Change of Equation of Russia’s Foreign and Defense Policy from Offence to Defense.” Thus, the paper is seeking a proper answer for the question “What are the reasons and Channels of Iran’s impact on Russian change of approach from offence to defense, and therefore, alleviation of security issues in Central Eurasia?”  The primary answer of the paper to the question lies in “Natural Alliance of Iran and Russia”, and the main reason of Iran’s influence on the development in the Offence-Defense equation of Russia is the “common threats and concerns of Iran and Russia from the West and compatibility of the two countries’ interests in stopping western expansionism in the northern and Western borders”. The current paper is of the Analytical-Descriptive type and the method used is inferential and the findings of the paper which are mostly analyzed based on references to objective-historical evidence and logical reasoning are proof of the truth of the primary answers.