The Nagorno-Karabakh crisis and the conflicts between Azerbaijan and Armenia in September 2020 and its impact on Other regional and international actors showed the geopolitical importance of this region and the effects of these crises on Iran, therefore, the present research is aimed at answering this question: What threats will the Zangez-Zor Corridor construction program have against the interests of the Islamic Republic of Iran? And in this regard, using the theory of regional security, the hypothesis has been proposed that the creation of Zangezzor Corridor in the territory of Armenia, based on the plans announced by the Republic of Azerbaijan-Turkey axis, can change the regional balance of power to the detriment of the Islamic Republic of Iran; Therefore, the advancement of this project is considered a security threat against the geopolitical and economic interests of the Islamic Republic of Iran, the most important of which are: the possibility of changing the geopolitical borders by blocking the land border between Iran and Armenia; The possibility of Armenia's convergence with the Western bloc and the intensification of the strategic isolation of the Islamic Republic of Iran; Reducing Iran's transit advantages in the North-South corridor; increasing Turkish influence in the region; jeopardizing national sovereignty and territorial integrity by advancing the Pan-Turkic plan and reviving Azari ethnocentrism; Strengthening the presence of NATO, Israel and Russia in the northern borders of the country. Also, descriptive analytical method has been used in this research and library information collection method has been used.