Deep geopolitical changes in the South Caucasus have had a significant impact on the relations between Iran and the Republic of Armenia. The geographical location and strategic importance have turned this region into one of the most important regions in the world, and the active presence of regional and extra-regional actors has had a direct impact on this relationship. This research seeks to evaluate the behavioral pattern of Iran and Armenia in the South Caucasus region, especially after the changes caused by the Second Karabakh War in 2020, because the Second Karabakh War changed the balance of regional power, the strategic environment and the perspective of arrangements. It has revolutionized the geopolitics of the South Caucasus. In this regard, the main question of the research is raised in this way, what was the behavior pattern of the Islamic Republic of Iran towards Armenia in the South Caucasus region? Using the concept of geo-polynomics, it is argued that Tehran's behavioral pattern to maintain the balance of power in the South Caucasus region is to expand the political, security and economic relationship with Armenia, especially after the second Karabakh war; Of course, geopolinomic concZangzor Corridor and military-intelligence exchange have remained strong, which after 2020 will increase tensions in the South Caucasus, especially between Iran and the opposite bloc. which includes Azerbaijan, Turkey and thonist regime. We do this important based on the descriptive-analytical approach using qualitative research methods that have been used in collecting information from documentary-library sources and authentic cyberspace websites.